Impact of 30 mg/kg amikacin and 8 mg/kg gentamicin on serum concentrations in critically ill patients with severe sepsis
نویسندگان
چکیده
منابع مشابه
Impact of 30 mg/kg amikacin and 8 mg/kg gentamicin on serum concentrations in critically ill patients with severe sepsis.
OBJECTIVES Low first-dose peak serum concentrations of amikacin and gentamicin are commonly reported in ICU patients. The present study aimed to assess whether 30 mg/kg amikacin or 8 mg/kg gentamicin achieved target concentrations in ICU patients with severe sepsis. PATIENTS AND METHODS Sixty-three ICU patients (Simplified Acute Physiology Score II = 43 ± 16) with severe sepsis and an indicat...
متن کاملImpact of an inducement to give high doses of amikacin and gentamicin on serum concentrations in critically ill patients with severe sepsis
Methods Single-center observational study. All ICU patients with clinical indication of aminoglycosides were eligible.ICU physicians were encouraged to administer maximal recommended doses of amikacin and gentamicin (30 and 8 mg/kg, respectively). The first and subsequent doses and corresponding peak plasma concentrations were recorded. Guideline targets for serum concentrations were used with ...
متن کاملStandard dosing of amikacin and gentamicin in critically ill patients results in variable and subtherapeutic concentrations.
Low peak plasma concentrations (Cmax) of amikacin and gentamicin are reported in intensive care unit (ICU) patients after administration of the first dose. The present study aimed to describe the proportion of ICU patients in whom an adequate Cmax was achieved throughout the course of therapy. Septic ICU patients with an indication for intravenous amikacin or gentamicin were eligible for inclus...
متن کاملSerum concentrations of vitamin A and oxidative stress in critically ill patients with sepsis.
INTRODUCTION Sepsis is one of the main causes of mortality in patients in Intensive Care Units. As a result of the systemic inflammatory response and of the decrease of the aerobic metabolism in sepsis, the oxidative stress occurs. Vitamin A is recognized by the favorable effect that it exerts on the immune response to infections and antioxidant action. OBJECTIVE To bring new elements for rev...
متن کاملTherapeutic monitoring of amikacin and gentamicin in critically and noncritically ill patients
OBJECTIVE Therapeutic drug monitoring (TDM) enables individualization in the treatment to optimize clinical benefit and minimize drugs' side effects. Critically ill septic patients represent a challenge for antimicrobial treatment because of pathophysiological impact of sepsis on pharmacokinetics of drugs. The aim of this study was to assess the appropriateness of gentamicin and amikacin dosing...
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ژورنال
عنوان ژورنال: Journal of Antimicrobial Chemotherapy
سال: 2015
ISSN: 0305-7453,1460-2091
DOI: 10.1093/jac/dkv291